bjectives : Of the several recent popular methods for measuring GFR using 99mTc-DTPA, it was reported that the Jackson urinary and russell two sample plasma methods are ore accurate tests. But both tests have never been applied to patints with
edema or
ascites.
In clinical practice, it is important to generate an accurate reproducible GFR in patients
with changing renal function.
Thus, we compared both tests with standard iothalamate clearance and evaluate the utility
of both tests in patients with increased ECF volume.
Methods : We measured Sigman's iothalamate clearance as a standard method and
simultaneously measured 99mTc-DTPA clearance with Jackson urinary and Russell plasma
methods in 20 patients with edema or ascites. In all patints 24 hour creatinine clearance was
mesured simultaneously.
Results :
1) The range of GFR by iothalamate clearance (IC) was from 11.5 ml/min to 148 ml/min.
2) The correlation between IC and creainine clearance was described by Y=0.88X + 8.30,
r=0.952(p<0.01).
3) The correlation between IC and Jackson urinary method was described by Y=0.88X +
8.30, r=0.972(p<0.01).
4) The correlation between IC and Russell plasma method was described by Y=0.72X +
28.07, r=0.904(p<0.095, 30', 180') and by Y=0.76X + 26.70, r=0.914(p<0.05, 60', 180').
Conclusion : Jackson urinary method appears to be most reliable and precise measures of
GFR in patients with increased ECF volume.
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